New Products in stock! Proudly made in USA. Shop now !

New Arrivals: BDBV 2026 Outbreak Sequence products are now live!

Fight the BDBV Outbreak: Shop Ready-to-ship Bundibugyo Reagents

Bacteremia NHP Model

Staphylococcus aureus bacteremia Non-Human Primate model

IBT Bioservices has developed a “NHP” model for evaluation of vaccines and therapeutics against bloodstream infections caused by Staphylococcus aureus infection. The model closely resembles the course of disease including following features. Animal models for Staphylococcus aureus (S. aureus) diseases are critical for evaluation of the efficacy of antibiotic treatment, or experimental vaccines and immunotherapeutics. S. aureus models developed so far have been limited to mice, rats, and guinea pigs. Bacterial pathogenesis in these S. aureus rodent models does not optimally reflect bacterial pathogenesis in humans. Nonhuman primate (NHP) models are the closest experimental models to humans. IBT Bioservices has developed a unique macaque model of S. aureus bacteremia (bloodstream infection) using cynomolgus macaques.

Features of this model in Cynomologus Macaques

  • Rapid development of bacteremia lasting for >7-10 days
  • 15% mortality rate
  • Loss of body weight (10-15%) with late recovery >
  • 30 days Spike in CRP, liver enzymes and markers of kidney damage, hematological abnormalities
This NHP model represents a unique model for testing the efficacy of novel antibiotics, vaccines, and immunotherapeutics as pivotal preclinical study prior to clinical trials.
Here’s a breakdown of the clinical course and blood chemistry changes observed in Cynomolgus macaques (NHPs) after intravenous infection with S. aureus USA300:

Clinical Course in NHPs

Bacteremia Levels:

After intravenous injection with S. aureus USA300, the macaques developed varying levels of bacteremia in their bloodstream.

Body Temperature:

Individual monkeys exhibited changes in body temperature following the S. aureus challenge.

Weight Loss:

On average, the infected macaques experienced weight loss after intravenous infection.

Changes in Blood Chemistry in Infected Macaques

Inflammatory Markers: C-reactive protein (CRP):

There was a sharp increase in CRP levels, which is a common indicator of infection and inflammation in humans. Albumin/Globulin Ratio: A decrease in the albumin/globulin ratio was observed, also consistent with infectious diseases and inflammation.

Liver Function Markers: Liver Enzymes (ALT, AST, GGT):

Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT) increased rapidly, suggesting liver damage. Total Bilirubin: An increase in total bilirubin was noted, which can indicate liver damage or increased red blood cell breakdown.

Kidney Function Marker: Blood Urea Nitrogen (BUN):

Elevated blood urea nitrogen (BUN) levels were observed upon infection, indicating kidney damage.

Muscle Damage Marker: Creatine Kinase:

An increase in creatine kinase levels suggested muscle damage in the infected NHPs.
In addition to this model IBT Bioservices offers a wide range of tools and models for your staphylococcal research:
Mouse models of S. aureus infection including pneumonia, bacteremia, and skin infections
Read More >

A wide range of assays for the study of staphylococcal toxins including well
developed serological IgG binding Luminex and toxin neutralization assays

Read More >

A large collection of reagents for staphylococcal research including purified
toxins and surface proteins as well as monoclonal and polyclonal antibodies.

 

Read More >
Read More About the NHP Model

Tell Us About Your Enquiry

    Share This

    Facebook
    Twitter
    LinkedIn

    CATEGORIES

    RECENT POSTS

    Combating Emerging Threats: Accelerating Broad-Spectrum Antivirals for BARDA’s SMART Initiative

    Read More

    Combating the 2026 Bundibugyo Outbreak: How IBT Bioservices Accelerates Vaccine and Therapeutic Development

    Read More

    Accelerating Flavivirus Therapeutics: Validated Assays from Discovery to Dose


    Read More

    SUBSCRIBE HERE!

    Subscribe to the IBT Bioservices Tech Talk list and receive periodic updates on industry news and IBT Bioservices products and services.

    CLICK TO SUBSCRIBE

    You may also like

    Search
    Generic filters