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Toxic Shock Syndrome caused by Staphylococcal enterotoxins A, B, C and TSST-1

We have established toxic shock models in BALB/c and C57/BL6 for staphylococcal enterotoxins A, B, C, and toxic shock syndrome toxin 1 (TSST-1).

The model utilizes Lipopolysaccharide (LPS) as a potentiating agent as described previously (Stiles, et al., 1993). Purified toxins are administered intraperitoneally followed by an injection of LPS 4 hours post challenge. Mice typically succumb to challenge within 24-72 hours. In addition to morbidity and mortality,
cytokine response can be measured at various time points post challenge using multiplex MSD assay. In vitro toxin neutralization assay of sera (using human PBMCs) is also available for vaccine studies.

KEY FEATURES

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S. Aureus Toxin

  • SAg A
  • SAg B
  • SAg C
  • TSST-1

Testing Available

  • In vivo efficacy, MIC/MBC, Superantigen Toxin Neutralization Assay
  • In vivo efficacy, MIC/MBC, Superantigen Toxin Neutralization Assay
  • In vivo efficacy, MIC/MBC, Superantigen Toxin Neutralization Assay
  • In vivo efficacy, MIC/MBC, Superantigen Toxin Neutralization Assay

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