Animal Models

Our experienced researchers utilize appropriate animal models, such as mice or nonhuman primates, to mimic Sudan virus infection and assess the safety and efficacy of potential treatments. IBT has developed lethal infections using Ag129 transgenic mice, who are deficient in IFN-α/β and IFN-γ receptors, infected with pseudo filoviruses to allow data collection in a BSL-2 safety setting. For our efficacy models, we closely monitor key parameters such as survival rates, viral titers, and immune responses to evaluate the effectiveness of the tested therapies. Our in vivo studies provide valuable data on the treatment’s ability to control viral replication, reduce disease severity, and improve overall outcomes. Available Animal Species and Strains: AG129 Mice, BALB/c Mice,CD-1 Mice,Hartley Guinea Pig