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Antiviral Assays

Tap into our off-the-shelf antiviral assay testing services to screen for anti-viral activity of your compounds against key virus families or let us help you select the appropriate assays for your specific compound and mechanism of action.

Our anti-viral assays are designed to evaluate the activity of your compound of interest. In addition to anti-viral activity, any of these assays can be further optimized or used in combination with complementary assays to determine mechanism of action. Moreover, complement these assays with our cytotoxicity

assays to ensure the anti-viral activity of your compounds are meaningful and within a reasonable therapeutic window. IBT also has quality systems in place to adapt our assays for clinical sample testing. Explore the multitude of anti-viral assays offered by IBT Bioservices below:

ANTI-VIRAL ASSAYS OVERVIEW:

Cytopathic Effect (CPE)

Our CPE inhibition assay can be used to assess a test article’s ability to hinder viral-induced cytopathic effect. This assay is ideal for compounds with mechanisms of action that impact the host cell.

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Microneutralization Assay

Another variant of the CPE assay is microneutralization, where the test samples are incubated and allowed to neutralize the virus before being incubated with cells.

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Yield Reduction Assay

Measuring an antiviral compound’s ability to decrease virus replication and subsequent viral yield in cell cultures using yield reduction assay. Following incubation, cell culture supernatants are collected, titrated via plaque assay & given as a titer (PFU/mL).

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Differential Scanning Fluorimetry Analysis

A high throughput stability-indicating assay to measure the melting temperature of your sample. The assay can be used to evaluate antibodies or proteins at varying formulations, stress conditions or stability timepoints that are generated over a temperature range of 30-100°C

Quantitative Suspension

Evaluate virucidal activity of chemical disinfectants within a given contact time in suspension.

Plaque Reduction Neutralization (PRNT)

Measure the level of virus-specific neutralizing antibodies in a sample using PRNT assays, providing insight into the immune response against a particular virus.

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TCID50

Evaluate TCID50, an endpoint dilution assay that can be used to calculate the viral titer of viruses by plaque assay. Plates are incubated until cytopathic effect (CPE) is observed in the virus control wells and then stained with crystal violet.

Antibody-Dependent Enhancement (ADE) Assay

ADE has been observed in viruses such as Dengue and Influenza, and poses a challenge in vaccine development. This occurs when non-neutralizing or sub neutralizing anti-viral proteins facilitate virus entry into host cells leading to enhanced infectivity. Using flow cytometry, plaque assay or qPCR, this assay can help elucidate the ADE effect of test articles on virus infection in Fc receptor bearing cells.

IBT HAS A VARIETY OF ESTABLISHED VIRUS PANELS

PSEUDOVIRUSES

Filovirus: Ebola virus Sudan virus Marburg virus Ravn Virus

Retrovirus: HIV

Henipavirus: Nipah Virus

Coronavirus: MERS-CoV SARS-CoV-2 SARS-CoV-2 Variants

VIRAL PANELS

Chikungunya Virus Dengue – Serotype 1,2,3 & 4 Human Cytomegalovirus (hCMV) Herpes Simplex Virus (HSV-1 & 2) Respiratory Syncytial Virus (RSV- A & B)

Influenza H1N1 Influenza H1N1 (Anti-viral resistant strains) Influenza H3N2 Influenza H3N2 (Anti-viral resistant strains) Influenza B (Yamagata Lineage/Victoria) Influenza B (Victoria Lineage)

Our Focus On Precision, Reliability And Customer Satisfaction Makes Us The Trusted Partner For Research Institutions, Pharmaceutical Companies, And Diagnostic Laboratories. We Provide You With High Quality Data And Documentation To Support Your Regulatory.

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