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Streptococcus pneumoniae Pneumonia Model

BALB/c or C57BL/6 mice are challenged intranasally with Streptococcus pneumoniae and observed for 5-15 days post infection.

Endpoints include mortality, morbidity, or CFU measurement (sub-lethal challenge) in blood, lung, spleen or other organs.

KEY FEATURES

Animal Background: Challenge Route: Challenge Dose: Mean Time to Death:

BALB/C, C57BL/6

Intranasal Instillation (IN)

Strain Dependent

Strain and Route Dependent
Standard Readouts: Other Readouts:

Weights, health and survival

Bacterial Assays (MIC), ELISA, Luminex, Flow cytometry, Survival, Temperature (via microchip), bacterial load in organs, Tissue pathology, etc.

Description: Female BALB/c mice were challenged with S. pneumonia via the intranasal instillation (IN). Mice were treated with either saline as control or two different
test articles.

S. pneumoniae Strains

  • DCC1335
  • DCC1420
  • 6b2092
  • D38 ST2

Testing Available

  • In vivo efficacy, MIC/MBC
  • In vivo efficacy, MIC/MBC
  • In vivo efficacy, MIC/MBC
  • In vivo efficacy, MIC/MBC

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