| Animal Background: | Challenge Route: | Challenge Dose: | Mean Time to Death: |
|---|---|---|---|
BALB/C, CD-1 |
Intranasal Instillation (IN) |
Model Dependent |
Day 2 |
| Standard Readouts: | Other Readouts: | ||
Weights, health and survival |
Description: Female BALB/c mice were challenged with
Staphylococcus aureus USA300 NRS384 at both LD50 and
LD90 doses via intranasal (IN) instillation.
Description: Female BALB/c (n=10) mice were treated via the intraperitoneally (IP) with two antibodies 2- hours before intranasal (IN) instillation with 1x LD90 of Staphylococcus aureus USA300 NRS384. The animals treated with the control antibody succumbed to infection by day 2 post-infection.
