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In Vitro & In Vivo Ebola Virus Models to Support Pre-clinical Research

Our team at IBT Bioservices has extensive experience in preclinical testing services to assess the viability and effectiveness of novel therapies against filorviruses including Ebola and Marburg viruses

Caused by

Ebola virus, which can cause outbreaks of highly contagious and life-threatening infections, with the potential for significant public health impact.

Transmission

Ebola virus is transmitted to humans from wild animals and then spreads through human-to-human transmission.

Symptoms

Sudden onset of fever, intense weakness, muscle pain, headache, and sore throat.

Virus Family

Belongs to the Filoviridae family and is part of the genus Ebolavirus

Research with filoviruses requires high containment laboratories significantly increasing the cost and timeline of therapeutic development. Our expert team of scientists have developed surrogate pseudo type models to perform a major portion of the preclinical testing under BSL2 conditions. We further partner with state-of-the-art BSL-4 facilities to conduct preclinical testing using the authentic Ebola and Marburg viruses. IBT Bioservices is a world leader in producing and offering unique reagents for filovirus research. We offers a diverse array of products and services designed to facilitate filovirus research for Ebolavirus, Sudan ebolavirus, and Marburg virus strains.

Our comprehensive range includes

Pseudoviruses specifically tailored for neutralization assays

Antibodies essential for detection in ELISA and Western blotting

Virus-like particles and glycoproteins

Rest assured, our reagents are of exceptional quality, and they are available for purchase to support your research endeavors.

Our preclinical testing services for filoviruses encompass a wide range of assessments, including:

In Vitro Studies

We employ cellular and molecular techniques to evaluate the antiviral activity of potential drugs against the Ebola virus. These studies help identify compounds that can effectively inhibit viral entry or replication and reduce viral load. IBT offers pseudovirus neutralization assay services and has a large inventory of Ebola isolates. We also have a wide range of antibodies targeting different regions on the glycoprotein as needed for functional assays. We can offer custom assay development services to suit your product development needs.

Regulatory Support

Our team assists in compiling and organizing preclinical data required for regulatory submissions, helping streamline the approval process and facilitate the transition from preclinical to clinical trials.

Animal Models

Our researchers have extensive experience with filovirus animal models. We can investigate the pathogenesis and therapeutic efficacy against infection in our BSL-4 partner laboratories or using a BSL-2 safety level within our own facility. We have developed lethal infections using Ag129 transgenic mice, who are deficient in IFN-α/β and IFN-γ receptors, infected with pseudo filoviruses. For our efficacy models, we closely monitor key parameters such as survival rates, viral titers, and immune responses to evaluate the effectiveness of the tested therapies. Our in vivo studies provide valuable data on the treatment’s ability to control viral replication, reduce disease severity, and assess the potential treatments’ safety and efficacy. Available Animal Species and Strains: AG129 Mice,BALB/c Mice,CD-1 Mice,Hartley Guinea Pig

At IBT, we are committed to advancing the field of Ebola research and development by providing reliable and accurate preclinical testing services. Our dedication to scientific excellence, ethical practices, and adherence to regulatory guidelines makes us a trusted partner in the fight against Ebola.

Contact us today to learn more about how our preclinical testing services can accelerate the development of promising treatments for Ebola and contribute to the global efforts to combat this deadly disease. 

 

REFRENCE NUMBER: 22050

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REFRENCE NUMBER: 22050

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REFRENCE NUMBER: 22050

REFERENCES

https://pubmed.ncbi.nlm.nih.gov/27608667/
Reference: 27608667
https://pubmed.ncbi.nlm.nih.gov/33536172/%20
Reference: 33536172
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