Description: Disease progression of ZIKA FSS13025 administered via the subcutaneous (SC) route in AG129 mice (n=15). All mice succumbed to infection by day 12 of the study when challenged with 1.00E+04 PFU/mouse.
Description: Reproductive tissues collected from infected mice 4-, 6-, and 8- days post infection were analyzed for viral load via plaque assay. Viral load in ovaries peaked at 6 days post infection while the viral load in testes continued to rise even at 8 days post infection.
Description: Serum and tissues collected from infected mice 2-, 4-, 6-, and 8-days post infection were analyzed for viral load via plaque assay. Serum viral load peaked at 4 days post infection while most tissue viral load peaked at 6 days post infection. IN LN= Inguinal lymph nodes. AUX LN= Auxiliary lymph nodes.