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Bacteremia NHP Model

Staphylococcus aureus bacteremia Non-Human Primate model

IBT Bioservices has developed a “NHP” model for evaluation of vaccines and therapeutics against bloodstream infections caused by Staphylococcus aureus infection. The model closely resembles the course of disease including following features. Animal models for Staphylococcus aureus (S. aureus) diseases are critical for evaluation of the efficacy of antibiotic treatment, or experimental vaccines and immunotherapeutics. S. aureus models developed so far have been limited to mice, rats, and guinea pigs. Bacterial pathogenesis in these S. aureus rodent models does not optimally reflect bacterial pathogenesis in humans. Nonhuman primate (NHP) models are the closest experimental models to humans. IBT Bioservices has developed a unique macaque model of S. aureus bacteremia (bloodstream infection) using cynomolgus macaques.

Features of this model in Cynomologus Macaques

This NHP model represents a unique model for testing the efficacy of novel antibiotics, vaccines, and immunotherapeutics as pivotal preclinical study prior to clinical trials.

Here’s a breakdown of the clinical course and blood chemistry changes observed in Cynomolgus macaques (NHPs) after intravenous infection with S. aureus USA300:

Clinical Course in NHPs

Bacteremia Levels:

After intravenous injection with S. aureus USA300, the macaques developed varying levels of bacteremia in their bloodstream.

Body Temperature:

Individual monkeys exhibited changes in body temperature following the S. aureus challenge.

Weight Loss:

On average, the infected macaques experienced weight loss after intravenous infection.

Changes in Blood Chemistry in Infected Macaques

Inflammatory Markers: C-reactive protein (CRP):

There was a sharp increase in CRP levels, which is a common indicator of infection and inflammation in humans. Albumin/Globulin Ratio: A decrease in the albumin/globulin ratio was observed, also consistent with infectious diseases and inflammation.

Liver Function Markers: Liver Enzymes (ALT, AST, GGT):

Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT) increased rapidly, suggesting liver damage. Total Bilirubin: An increase in total bilirubin was noted, which can indicate liver damage or increased red blood cell breakdown.