An animal model is a non-human species used in biomedical research because it can mimic aspects of a biological process or disease found in humans.
Disease-to-target discovery is the process of identification and early validation of targets involved in a disease.
Animal Background | Challenge Route | Mean Time to Death | |
---|---|---|---|
Balb/C, C57Bl6 |
Intranasal (IN) |
7 Days (Strain Dependent) |
|
Peak Viremia | Standard Readouts | Other Readouts | |
4-5 Days |
Weights, Health And Survival |
CPE Assay, HAI Assay, PRNT, Microneutralization assay, Pseudovirus neutralization assay, ELISA, Luminex, |
Description: Female BALB/c mice were treated with two antibodies 1-hour prior to inoculation with LD90 of Influenza H3N2 A/Hong Kong/1/68 via the intranasal (IN) route. The mean time of death for this virus strain falls on day 6.
Description: Female BALB/c mice were treated with two antibodies 24-hours before inoculation with 1.00E+05 PFU/animal of Influenza B/Florida/04/2006 (Yamagata
lineage) via the intranasal (IN) route. The mean time of death for this virus strain falls on day 7.
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