| Animal Background: | Challenge Route: | Challenge Dose: | Mean Time to Death: |
|---|---|---|---|
BALB/C, CD-1 |
Intraperitoneal (IP), Intravenous (IV) |
Strain Dependent |
Strain and Route Dependent |
| Standard Readouts: | Other Readouts: | ||
Weights, health and survival |
Bacterial Assays (MIC), ELISA, Luminex, Flow cytometry, Bacterial load in organs |
Description: Female BALB/c (n=75) mice were challenged with varying doses of USA300 NRS384 via the intravenous (IV) route.
Description: Female BALB/c (n=190) mice were challenged with varying doses of USA300 NRS384 via the intraperitoneal (IP) route.
Description: Female BALB/c (n=30) mice were challenged with 1x LD90 of USA300 NRS384 via the intraperitoneal (IP) route. All animals were challenged on day 0 and received treatment via the IP route twice daily for five days.
