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AG129 Mouse Model

AG129 mice are a valuable model organism that can provide valuable insights into immune responses and infectious diseases. IBT Bioservices we can supply AG129 Mice for animal studies or breed colonies for our clients.
AG129 mice are a unique strain of laboratory mice that have a compromised immune system due to the knockout of two crucial immune-related genes: the interferon alpha/beta receptor (IFNAR) and the interferon gamma receptor (IFNGR). These receptors play a crucial role in the immune response against viral infections, and their absence in AG129 mice makes them highly susceptible to a wide range of viruses.
This double knockout mouse model is commonly used in the study of arboviruses, including Dengue, Zika, Chikungunya, and West Nile viruses. The AG129 mouse model also provides a platform for evaluating anti-virals against highly pathogenic Ebola and Marburg viruses, through pseudoviruses in a BSL-2 setting. This capability reduces the economic and logistical burden of BSL-3 and BSL-4 testing and handling requirements.

Here are some ways in which the AG129 mouse model can be used to evaluate and advance preclinical therapeutics.

Increased Viral Susceptibility

Increased Viral Susceptibility

Due to the absence of IFNAR and IFNGR, AG129 mice lack an effective innate immune response against viral infections. This heightened susceptibility to various viruses, including flaviviruses, alphaviruses, and Ebola and Sudan pseudoviruses filoviruses others, makes them a valuable model for studying viral pathogenesis, viral-host interactions, and vaccine development.

Disease Modeling

Disease Modeling

AG129 mice are widely used as models to study viral diseases, including dengue fever, Japanese encephalitis, Zika virus infection, Chikungunya virus, and more. These mice closely mimic the clinical manifestations observed in humans infected with these viruses, allowing researchers to investigate disease progression, immune responses, and potential therapeutic interventions.

Vaccine Development

Vaccine Development

AG129 mice provide a critical platform for evaluating the efficacy and safety of vaccines against viral infections. Since these mice are highly susceptible to viral diseases, researchers can assess the protective immune responses elicited by candidate vaccines and evaluate their ability to prevent or control infections. These studies contribute to the development of effective vaccines for human use.

Immune Response Studies

Immune Response Studies

AG129 mice offer a unique opportunity to study the intricate dynamics of immune responses during viral infections. Researchers can investigate the role of specific immune cells, cytokines, and signaling pathways in viral clearance, pathogenesis, and immunopathology. These studies deepen our understanding of host-virus interactions and inform the development of antiviral strategies.
The findings obtained from AG129 mouse studies have significant translational relevance for human health. Insights gained from these studies can help in the design and development of antiviral therapeutics, vaccines, and diagnostic tools. AG129 mice serve as a critical bridge between basic research and clinical applications in the fight against infectious diseases.
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