Toxic Shock Syndrome caused by Staphylococcal enterotoxins A, B, C and TSST-1

We have established toxic shock models in BALB/c and C57/BL6 for staphylococcal enterotoxins A, B, C, and toxic shock syndrome toxin 1 (TSST-1).

The model utilizes Lipopolysaccharide (LPS) as a potentiating agent as described previously (Stiles, et al., 1993). Purified toxins are administered intraperitoneally followed by an injection of LPS 4 hours post challenge. Mice typically succumb to challenge within 24-72 hours. In addition to morbidity and mortality,
cytokine response can be measured at various time points post challenge using multiplex MSD assay. In vitro toxin neutralization assay of sera (using human PBMCs) is also available for vaccine studies.

KEY FEATURES

Animal Background: Challenge Route: Challenge Dose: Mean Time to Death:

BALB/C, C57BL/6

Intraperitoneal (IP)

Toxin Dependent

Toxin Dependent

Standard Readouts: Other Readouts:

Weights, health and survival

Bacterial Assays (MIC), ELISA, Luminex, Flow cytometry, Survival, Temperature (via microchip), bacterial load in organs, Tissue pathology, etc.

.ayt_acfwc_properti { width: 100%; border-collapse: collapse; margin: 1.5em 0; font-family: inherit; } .ayt_acfwc_properti th, .ayt_acfwc_properti td { padding: 14px 16px; border: 1px solid #ddd; text-align: left; vertical-align: top; } .ayt_acfwc_properti th { background-color: #f5f5f5; font-weight: 600; } /* 🔹 Responsive Table */ @media screen and (max-width: 768px) { .ayt_acfwc_properti, .ayt_acfwc_properti thead, .ayt_acfwc_properti tbody, .ayt_acfwc_properti th, .ayt_acfwc_properti td, .ayt_acfwc_properti tr { display: block; width: 100%; } .ayt_acfwc_properti tr { margin-bottom: 1.2em; border: 1px solid #ddd; border-radius: 8px; overflow: hidden; background: #fff; } .ayt_acfwc_properti th { background: #2b2b2b; color: #fff; padding: 10px; border: none; border-bottom: 1px solid #444; text-align: left; } .ayt_acfwc_properti td { padding: 10px; border: none; border-top: 1px solid #eee; } .ayt_acfwc_properti tr.heading-row { display: none; /* Hide duplicate headers on small screens */ } .ayt_acfwc_properti tr.description-row td { display: block; } .ayt_acfwc_properti tr.description-row td::before { content: attr(data-label); display: block; font-weight: bold; margin-bottom: 5px; color: #333; } }

No images found in the slider.

S. Aureus Toxin

  • SAg A
  • SAg B
  • SAg C
  • TSST-1

Testing Available

  • In vivo efficacy, MIC/MBC, Superantigen Toxin Neutralization Assay
  • In vivo efficacy, MIC/MBC, Superantigen Toxin Neutralization Assay
  • In vivo efficacy, MIC/MBC, Superantigen Toxin Neutralization Assay
  • In vivo efficacy, MIC/MBC, Superantigen Toxin Neutralization Assay

Search
Generic filters