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Toxic Shock Syndrome caused by Staphylococcal enterotoxins A, B, C and TSST-1

We have established toxic shock models in BALB/c and C57/BL6 for staphylococcal enterotoxins A, B, C, and toxic shock syndrome toxin 1 (TSST-1).

The model utilizes Lipopolysaccharide (LPS) as a potentiating agent as described previously (Stiles, et al., 1993). Purified toxins are administered intraperitoneally followed by an injection of LPS 4 hours post challenge. Mice typically succumb to challenge within 24-72 hours. In addition to morbidity and mortality,
cytokine response can be measured at various time points post challenge using multiplex MSD assay. In vitro toxin neutralization assay of sera (using human PBMCs) is also available for vaccine studies.

KEY FEATURES

Animal Background: Challenge Route: Challenge Dose: Mean Time to Death:

BALB/C, C57BL/6

Intraperitoneal (IP)

Toxin Dependent

Toxin Dependent
Standard Readouts: Other Readouts:

Weights, health and survival

Bacterial Assays (MIC), ELISA, Luminex, Flow cytometry, Survival, Temperature (via microchip), bacterial load in organs, Tissue pathology, etc.

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S. Aureus Toxin

  • SAg A
  • SAg B
  • SAg C
  • TSST-1

Testing Available

  • In vivo efficacy, MIC/MBC, Superantigen Toxin Neutralization Assay
  • In vivo efficacy, MIC/MBC, Superantigen Toxin Neutralization Assay
  • In vivo efficacy, MIC/MBC, Superantigen Toxin Neutralization Assay
  • In vivo efficacy, MIC/MBC, Superantigen Toxin Neutralization Assay

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