Respiratory Syncytial Virus Efficacy Model

RSV infection is responsible for a significant number of respiratory diseases in infants and morbidity in elderly populations. The cotton rat (S. hispidus) is susceptible to non-adapted human RSV.

Animals are infected by intranasal inoculation with RSV-A2. This is a non-lethal model that has been used to successfully test RSV vaccine and therapeutic candidates leading to IND and clinical development. Model kinetics indicate peak viral burden at day 4 or 5 post challenge followed by recovery through day7.
The best indicator of efficacy is viral load at the peak of infection and lung viremia is an indicator of morbidity.

KEY FEATURES

Animal Background: Challenge Route: Peak Lesion Size: Standard Readouts:

BALB/C, CD-1

Intradermal (ID)

Strain dependent

Weights, health, survival, lesions, photographs

Other Readouts:

Bacterial Assays (MIC), ELISA, Luminex, Flow cytometry

Strain

  • RSV-A A2
  • RSV-A Long
  • RSV-A 9320
  • RSV-A 18537
  • RSV-B WV 14617-85

Testing Available

  • Cotton Rat Efficacy, Viral Neutralization Assays
  • Viral Neutralization Assays
  • Viral Neutralization Assays
  • Viral Neutralization Assays
  • Viral Neutralization Assays

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