RSV infection is responsible for a significant number of respiratory diseases in infants and morbidity in elderly populations. The cotton rat (S. hispidus) is susceptible to non-adapted human RSV.
Animals are infected by intranasal inoculation with RSV-A2. This is a non-lethal model that has been used to successfully test RSV vaccine and therapeutic candidates leading to IND and clinical development. Model kinetics indicate peak viral burden at day 4 or 5 post challenge followed by recovery through day7.
The best indicator of efficacy is viral load at the peak of infection and lung viremia is an indicator of morbidity.
Description: Lung viremia data (plaque assay) collected from
cotton rats challenged with 1x LD90 of Respiratory syncytial virus
(A2) via the intranasal (IN) route.
Description: Lung viremia data (plaque assay) collected from
cotton rats challenged with 1x LD90 of Respiratory syncytial virus
(A2) via the intranasal (IN) route.