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Pharmacodynamic, Biodistribution & Pharmacokinetic Services

IBT, a leading preclinical CRO, can help you with your Pharmacokinetic (PK) and biodistribution studies. Partner with us to harness invaluable insights and elevate your drug development process. With our expertise, you can confidently navigate the complexities of drug distribution and metabolism, paving the way for safer, more effective treatments.

By analyzing PK parameters in rodents, our research optimizes dosage regiments to achieve the perfect balance of therapeutic effects while minimizing side effects and toxicity. Our PK studies delve deep into understanding how drugs are metabolized and excreted from the body, providing critical insights into drug elimination.
But we don’t stop there. Our biodistribution studies are pivotal in uncovering how drugs accumulate in specific tissues or organs over time. This knowledge is vital for assessing both efficacy and potential toxicity, ensuring that therapeutic agents reach their target sites effectively. Let’s transform healthcare together, one breakthrough at a time.

KEY FEATURES

Animal Background: Treatment Administration: Collection Timepoints: Readouts:

Cannulated Sprague Dawley Rats, Mice, HcRn mice, Guinea pigs, Custom Model Development

Intravenous, Intramuscular, Subcutaneous, Footpad, Intradermal, Oral gavage, Retro-orbital, Nebulizer, Sublingual

Various

Animal Clinical Observations, serum transfer, qPCR, organ harvests, anti-ID assays, histopathology, ELISA, Luminex, Flow cytometry

Description: Pharmacokinetics timeline for antibody delivery and sample collections in cannulated Sprague Dawley rats. Blood was collected at several time points using a catheter: 5 minutes, 30 minutes, 1 hour, 2 hours, 4 hours, 8 hours, 24 hours, 48 hours, 96 hours, 192 hours, and 384 hours after the antibody was delivered intravenously. The serum was separated from the whole blood and analyzed through ELISA.

Animal Strain

  • Cannulated Sprague Dawley Rats
  • HcRn mice
  • C57-Bl/6, Balb/C
  • Guinea pigs

Models

  • PK/ PD
  • PK/ PD
  • PK / PD, Biodistribution
  • PK / PD, Biodistribution

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