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Pharmacokinetics, Pharmacodynamics and Biodistribution

Pharmacokinetic (PK) studies are conducted to understand how drugs are eliminated from the body, mainly through metabolism and excretion processes. This knowledge helps in determining the drug’s half-life and dosing intervals. Researchers study PK parameters in rodents to optimize dosage regimens that achieve desired therapeutic effects while minimizing side effects and toxicity. Similarly,
biodistribution studies help us understand whether drugs accumulate in specific tissues or organs over time, which can affect both efficacy and potential toxicity. These studies provide insights into how drugs or therapeutic agents distribute within various tissues and organs in the body, which is crucial for assessing the drug’s potential efficacy in reaching its target site.

KEY FEATURES

Animal Background: Treatment Administration: Collection Timepoints: Readouts:
Cannulated Sprague Dawley Rats, Mice, HcRn mice, Guinea pigs, Custom Model Development Intravenous, Intramuscular, Subcutaneous, Footpad, Intradermal, Oral gavage, Retro-orbital, Nebulizer, Sublingual Various Animal Clinical Observations, serum transfer, qPCR, organ harvests, anti-ID assays, histopathology, ELISA, Luminex, Flow cytometry

Description: Pharmacokinetics timeline for antibody delivery and sample collections in cannulated Sprague Dawley rats. Blood was collected at several time points using a catheter: 5 minutes, 30 minutes, 1 hour, 2 hours, 4 hours, 8 hours, 24 hours, 48 hours, 96 hours, 192 hours, and 384 hours after the antibody was delivered intravenously. The serum was separated from the whole blood and analyzed through ELISA.

Animal Strain

  • Cannulated Sprague Dawley Rats
  • HcRn mice
  • C57-Bl/6, Balb/C
  • Guinea pigs

Models

  • PK/ PD
  • PK/ PD
  • PK / PD, Biodistribution
  • PK / PD, Biodistribution