Animal models for Staphylococcus aureus (S. aureus) diseases are critical for evaluation of the efficacy of antibiotic treatment, or experimental vaccines and immunotherapeutics. S. aureus models developed so far have been limited to mice, rats, and guinea pigs. Bacterial pathogenesis in these S. aureus rodent models does not optimally reflect bacterial pathogenesis in humans. Nonhuman primate (NHP) models are the closest experimental models to humans. IBT Bioservices has developed a unique macaque model of
S. aureus bacteremia (bloodstream infection) using cynomolgus macaques.
IBT’s NHP model closely resembles S. aureus bacterial pathogenesis in human bacteremia and septicemic patients. Intravenous injection of cynomolgus monkeys with S. aureus USA300 led to rapid development of bacteremia disease with features of human disease such as:
A) bacteremia level in the bloodstream after intravenous injection with S. aureus USA300. One of the animals (NHP#3) died 10 days post infection and this monkey exhibited the highest level of bacteremia before death.
B) Body temperature in individual monkeys post challenge.
C) Average weight loss in macaques after IV infection.
A&B) Sharp increase in CRP and decrease in Albumin/Globulin ratio response to S. aureus infection, markers normally increased in human infectious diseases and inflammation.
C) Upon infection the liver enzymes ALT, AST, and GGT increase rapidly, indicating liver damage.
D) Increased total bilirubin in the infected NHPs indicative of liver damage or red blood cell breakdown.
E) Increased blood urea nitrogen (BUN) upon infection indicating kidney damage.
F) Increased creatine kinase indicating muscle damage.
In addition to this model IBT Bioservices offers a wide range of tools and models for your staphylococcal research:
Mouse models of S. aureus infection including pneumonia, bacteremia and skin infections
A wide range of assays for the study of staphylococcal toxins including well
developed serological IgG binding Luminex and toxin neutralization assays.
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