Description: INFV H1N1 A/Puerto Rico/08/34 dose determination study in BALB/C mice when treated with 20mg/kg of oseltamivir phosphate twice daily for five days. Meta-analysis of seven independent studies (n=45).
Description: 10 mice were inoculated via intranasal instillation with 1.00E+05 PFU/mouse of A/Perth/261/2009 MH25Y (oseltamivir phosphate resistant strain). On day 4 post-infection, all animals were sacrificed, and lungs were harvested. Lungs were homogenated and final supernatants were titrated via plaque assay. The passage 1 (P1) lung supernatants were then used to infect new BALB/C mice.
