Vaccine Adjuvant Screening Services for Clinical & Preclinical Testing

IBT Bioservices offers extensive vaccine adjuvant screening services to bolster the development and refinement of vaccines and modern medical treatments. Adjuvants are pivotal in boosting vaccine-induced immune responses by enhancing antigen presentation, activating innate immune pathways, and fostering enduring immunity.

Our assay services can aide in the evaluation of complex formulations to assess adsorption and solubility. Additionally, our vivarium services provide a solid platform for screening and evaluating optimal formulations, administration routes, dosages, and frequencies. Our proficient staff and veterinarian offer thorough analyses of safety and reactogenicity parameters vital for developing safe and effective adjuvants.

In conjunction with immunogenicity and safety assessments, complement your research with endpoint assays such as flow cytometry, ELISA, and multiplex Luminex assays. These assays delve into immune mechanisms and cytokine roles, facilitating the advancement of next-generation immune modulators.

Key Features of Our Vaccine Adjuvant Screening

1. Customized Screening Assays:

We understand that each vaccine project has unique requirements, and we tailor our screening assays to meet your specific needs. Our team of experienced scientists works closely with you to design and optimize the screening assays, taking into consideration the vaccine target, desired immune response, and specific adjuvant characteristics. We offer a range of in vitro and in vivo screening assays to assess adjuvant efficacy and safety.

2. In Vitro Screening Assays:

Our in vitro screening assays allow for the initial evaluation of adjuvant candidates in a controlled laboratory setting. These assays often involve cell-based models to assess the adjuvant’s ability to activate immune cells, stimulate cytokine production, and enhance antigen uptake and presentation. We utilize relevant cell lines and primary immune cells to mimic the physiological conditions and evaluate the adjuvant’s impact on immune responses.

3. In Vivo Screening Assays:

To evaluate adjuvant performance in a more complex and realistic setting, we offer in vivo screening assays using animal models. Our experienced team designs and conducts studies to assess the adjuvant’s ability to enhance immune responses in vaccinated animals. These assays measure antigen-specific antibody titers, cellular immune responses, and other relevant immunological parameters. We adhere to ethical guidelines and animal welfare regulations to ensure responsible and humane use of animals in research.

4. Immunological Assays and Biomarker Analysis:

5. Safety and Toxicity Assessment:

In addition to evaluating adjuvant efficacy, we also conduct safety and toxicity assessments as an integral part of our screening services. We monitor for potential adverse effects, local and systemic reactions, and overall safety profile of the adjuvant candidates. Our team follows rigorous protocols to ensure the safety of the vaccine formulation and minimize potential risks.

6. Data Analysis and Interpretation:

Our team of experts provides comprehensive data analysis and interpretation for adjuvant screening results. We utilize advanced statistical analysis tools and visualization techniques to assess adjuvant performance and identify the most promising candidates for further development. We deliver detailed reports summarizing the findings and assisting you in making informed decisions for your vaccine development program.

7. Confidentiality and Collaboration:

We prioritize confidentiality and understand the importance of protecting your intellectual property. We work under strict confidentiality agreements and provide a collaborative approach to ensure a seamless partnership. Your research and data are handled with the utmost professionalism and integrity.

At IBT Bioservices, we are dedicated to providing you with reliable and comprehensive vaccine adjuvant screening services. Our state-of-the-art facilities, cutting-edge technologies, and experienced scientific team make us the preferred partner for vaccine developers, academic researchers, and pharmaceutical companies.

Contact us today to discuss your vaccine adjuvant screening requirements and learn how we can support your vaccine development program.

CD-1 mice were vaccinated with SARS-CoV2 RBD Antigen and complexed with three different Advax adjuvants from Vaxine intramuscularly. Terminal sera from vaccinated mice show varying neutralization titers against several variants of concern (VoC) in pseudovirus neutralization assay.

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Vaccine Adjuvant Screening Services for Clinical & Preclinical Testing

Key Features of Our Vaccine Adjuvant Screening

1. Customized Screening Assays:

2. In Vitro Screening Assays:

3. In Vivo Screening Assays:

4. Immunological Assays and Biomarker Analysis:

5. Safety and Toxicity Assessment:

6. Data Analysis and Interpretation:

7. Confidentiality and Collaboration:

Contact us today to discuss your biodistribution study requirements and learn how we can support your research and development program.

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