Custom Animal Models

IBT has a well-equipped, modern facility with experienced scientists, a passionate animal care team and IACUC.

We can collaborate with you to develop rodent models that support development of your biologics and vaccines. This will enable your research to proceed smoothly.

KEY FEATURES

Animal Background:	Age Ranges:	Inoculations:	Therapeutic Agents:
Mice, Rats, Cotton rats, Guinea Pigs, Hamsters	Neonates to elderly	BSL-2 pathogens, peptides, small molecules, etc.	antibodies, small molecules, adjuvant mediated, new constructs, etc.
Housing:	Treatment Administration Routes:	Readouts:	Regulation:
Specialized housing for Immunocompromised mice, double filter Individual ventilated cages and racks	Intravenous, Intramuscular, Subcutaneous, Footpad, Intradermal, Oral gavage, Retro-orbital, Nebulizer, Sublingual	Animal health, weight, and survival data, CPE Assay, HAI Assay, PRNT, Microneutralization assay, Pseudovirus neutralization assay, ELISA, Luminex, Flow cytometry, lung and BAL viremia, Temperature (internal microchips)	Attending veterinarian, engaged IACUC committee

Description: INFV H1N1 A/Puerto Rico/08/34 dose determination study in BALB/C mice when treated with 20mg/kg of oseltamivir phosphate twice daily for five days. Meta-analysis of seven independent studies (n=45).

Description: 10 mice were inoculated via intranasal instillation with 1.00E+05 PFU/mouse of A/Perth/261/2009 MH25Y (oseltamivir phosphate resistant strain). On day 4 post-infection, all animals were sacrificed, and lungs were harvested. Lungs were homogenated and final supernatants were titrated via plaque assay. The passage 1 (P1) lung supernatants were then used to infect new BALB/C mice.

Example Models that can be developed at IBT Bioservices

Pathogen

Staphylococcus aureus
Klebsiella pneumoniae
Klebsiella pneumoniae
Enterococcus faecalis
Moraxella catarrhalis
Non-typable Haemophilus influenzae
Acinetobacter baumanii
Herpes Simplex Virus (HSV-2)
Various BSL-2 Viral and Bacterial Pathogens

Disease Model

IV Bacteremia
GI infection leading to hepatic infection
Pneumonia
IV Bacteremia
Pneumonia
Pneumonia
Pneumonia
Genital herpes
Custom Model Development.

IN-VITRO Services

ANIMAL SERVICES

By Diseases Target