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Custom Animal Models

IBT has a well-equipped, modern facility with experienced scientists, a passionate animal care team and IACUC.

We can collaborate with you to develop rodent models that support development of your biologics and vaccines. This will enable your research to proceed smoothly.

KEY FEATURES

Animal Background: Challenge Route: Peak Lesion Size: Standard Readouts:

BALB/C, CD-1

Intradermal (ID)

Strain dependent

Weights, health, survival, lesions, photographs
Other Readouts:

Bacterial Assays (MIC), ELISA, Luminex, Flow cytometry

Description: Two groups of Balb/C mice were infected with 1.00E+07 CFU/mouse of Staphylococcus aureus USA300 (NRS384) on day 0 via the intradermal (ID) route. One group received the experimental vaccine while the other group served as infection only control. On Day 49 of the study, both groups were infected with 1.00E+08 CFU/mouse and monitored for an additional 14 days. Lesion areas of vaccinated and non-vaccinated mice after primary and secondary infection.

Description: Two groups of Balb/C mice were infected with 1.00E+07 CFU/mouse of Staphylococcus aureus USA300 (NRS384) on day 0 via the intradermal (ID) route. One group received the experimental vaccine while the other group served as infection only control. On Day 49 of the study, both groups were infected with 1.00E+08 CFU/mouse and monitored for an additional 14 days. Lesion areas of vaccinated and non-vaccinated mice after primary and secondary infection.

Description: Two groups of Balb/C mice were infected with 1.00E+07 CFU/mouse of Staphylococcus aureus USA300 (LAC) on day 0.
One group received a novel vaccine candidate while the other group served as control receiving BCA.

Example Models that can be developed at IBT Bioservices

Pathogen

  • Staphylococcus aureus​
  • Klebsiella pneumoniae​
  • Klebsiella pneumoniae​
  • Enterococcus faecalis​
  • Moraxella catarrhalis
  • Non-typable Haemophilus influenzae​
  • Acinetobacter baumanii
  • Herpes Simplex Virus (HSV-2)
  • Various BSL-2 Viral and Bacterial Pathogens

Disease Model

  • IV Bacteremia​
  • GI infection leading to hepatic infection​
  • Pneumonia​
  • IV Bacteremia​
  • Pneumonia​
  • Pneumonia​
  • Pneumonia​
  • Genital herpes
  • Custom Model Development.

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