An animal model is a non-human species used in biomedical research because it can mimic aspects of a biological process or disease found in humans.
Disease-to-target discovery is the process of identification and early validation of targets involved in a disease.
Animal Background: | Challenge Route: | Mean Time to Death: | Standard Readouts: |
---|---|---|---|
AG129 | Strain dependent | Strain dependent | Weights, health and survival |
Other Readouts | |||
CPE Assay, HAI Assay, PRNT, Microneutralization assay, Pseudovirus neutralization assay, ELISA, Luminex, Flow cytometry, lung and BAL viremia, Temperature (internal microchips) |
Description: Disease progression of dengue-2 D2Y98P and S221 strains in AG129 mice (n=15). DENV-2 D2Y98P was administered via the subcutaneousroute (SC), while S221 was inoculated
via the intravenous (IV) route).
Description:Serum collected from AG129 mice infected with dengue virus, serotype- 2 (S221) was assessed by plaque assay (Figure
1) and qRT-PCR (Figure 2) for the detection of viral load at various timepoints.