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A pseudovirus neutralization assay is used to assess the ability of antibodies to neutralize the infectivity of a pseudovirus, which are created by packaging a non-replicating viral genome with the envelope proteins or surface antigens of another virus. Pseudoviruses are designed for various research purposes, particularly in virology and immunology, to study the infectivity and neutralization of specific viral proteins or antigens.

PSEUDOVIRUS NEUTRALIZATION ASSAY SERVICES

Antibodies against rVSV-SARS-CoV-2 (Wuhan strain) were tested in a Pseudovirus Neutralization Assay

Ab1 and Ab2 are antibodies tested against pseudovirus rVSV-SARS-CoV-2 (Wuhan strain) in our Pseudovirus NeutralizationAssay (PsVNA). Both antibodies exhibit similar neutralization profiles and have comparable neutralizing activity. A commercially available IgG1 anti-SARS-CoV-2 neutralizing antibody is included as a positive control.

Antibodies against rVSV-MARV-Angola were tested in a Pseudovirus Neutralization Assay

Antibodies 1-5 were assessed for the neutralization capability against rVSV-MARV Angola in a pseudovirus neutralization assay. All antibodies demonstrate neutralization of rVSV-MARV Angola. The neutralization curves for Antibodies 1 and 2 have similar profiles and more neutralizing potency is observed in Antibodies 1 and 2 when compared to Antibodies 3, 4, and 5.

The pseudovirus neutralization assay is a valuable methodology in virology and immunology for studying the neutralizing capacity of antibodies against specific viral proteins or antigens. The pseudovirus neutralization assay is based on the principle that neutralizing antibodies have the capacity to block the infectivity of pseudoviruses, which express the surface proteins of the target virus. This assay allows the study of specific antibodies that target viral entry mechanisms.

OUR PATHOGENS

We have a large panel of strains available and the ability to develop the assay for previous and emerging influenza strains.
  • Strains/Lineages
  • Filovirus:EBOV (Zaire)
  • Filovirus:SUDV (Gulu & Boniface)
  • Filovirus:MARV (Angola, Ci67, Musoke)
  • Filovirus:RAVV (Ravn)
  • SARS-CoV2:Common Name (Origin)
  • SARS-CoV2:Wild-type (Wuhan)
  • SARS-CoV2:Alpha (United Kingdom)
  • SARS-CoV2:Beta (South Africa)
  • SARS-CoV2:Gamma (Brazil)
  • SARS-CoV2:Delta (India)
  • SARS-CoV2:Epsilon (California, USA)
  • SARS-CoV2:D614G (–)
  • SARS-CoV2:Lambda
  • SARS-CoV2:Mu
  • SARS-CoV2:Omicron & other Omicron versions

We have a large panel of pseudoviruses available to work with and have the ability to develop custom pseudovirus neutralization assays to meet your specific research needs.

Ebola Virus-Like Particles

Marburg Virus-Like Particles

Sudan Virus-Like Particles

SARS-CoV-2 Virus-Like Particles

HIV Virus-Like Particles

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With years of experience in the field, our team of skilled scientists and technicians are well-versed in conducting assays involving a wide range of pseudoviruses. We utilize state-of-the-art equipment and follow stringent quality control measures to ensure precise and reproducible results.

OUR EXPERTISE

KEY APPLICATIONS OF PSEUDOVIRUS NEUTRALIZATION ASSAYS

Vaccine Development

Pseudovirus Neutralization Assays are essential for assessing the efficacy of vaccines by measuring their ability to induce neutralizing antibodies against specific viral proteins or antigens.

Viral Entry Studies

These assays allow the study of antibodies targeting the viral entry process, a critical step in the viral life cycle.

Immunology Research

Pseudovirus Neutralization Assays are widely used in the investigation of the immune response to viral infections and the evaluation of antiviral treatments.

Viral Variants

Researchers can use pseudoviruses carrying different viral variants or mutants to study how neutralizing antibodies respond to various strains of the virus.

WHY CHOOSE IBT?

EXPERTISE

Our team of scientists and technicians are highly skilled and experienced in conducting HAI assays, ensuring accurate and reliable results.

CUSTOMIZED SOLUTIONS

We understand the unique needs of each research project and provide customized assay designs to meet your specific requirements.

TIMELY RESULTS

We prioritize efficiency without compromising on quality. Our streamlined processes and advanced equipment allow for quick turnaround times, ensuring you receive results promptly.

QUALITY ASSURANCE

We maintain rigorous quality control measures throughout our operations, ensuring the accuracy and reproducibility of our assay results.

EXCEPTIONAL CUSTOMER SUPPORT

Our dedicated customer support team is always available to address your queries and provide assistance at every step of the process.