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Cytotoxicity studies aim to investigate the harmful effects of various agents on living cells, particularly focusing on their potential to cause cell death or damage. These studies play a vital role in fields such as pharmaceuticals, environmental sciences, and toxicology, helping researchers assess the safety and effectiveness of substances.

CYTOTOXICITY STUDIES

CYTOTOXICITY OF SMALL MOLECULES 1 AND 2

Cytotoxicity data is graphed using luminescence in relative light units (RLU). Cells were incubated with small molecules 1 and 2 for a predetermined amount of time and Cell Titer Glo® was added to the cells to obtain RLU readings.

% CYTOTOXICITY OF SMALL MOLECULES 1 AND 2

Small molecules 1 and 2 were tested for cytotoxicity in A549 cells. After a 72-hour incubation, small molecule 1 is toxic at most of the tested concentrations. Small molecule 2 is slightly toxic at the highest tested concentrations and nontoxic for the remaining tested concentrations.

Cell viability refers to the overall health and survival of cells. In cytotoxicity studies, researchers evaluate the viability of cells after exposure to different substances or conditions. By assessing cell viability, researchers can determine the impact of a substance on cell health and its potential toxic effects.

OUR PATHOGENS

We have a large panel of strains available and the ability to develop the assay for previous and emerging influenza strains.

We offer a wide array of methods to assess cytotoxicity and can create assays tailored to meet your specific research requirements.

ATP-Based Assays

MTT Assay

Lactate Dehydrogenase (LDH) Release Assay

Caspase Activity Assays

Flow Cytometry

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At IBT, we specialize in cytotoxicity studies and offer a range of services to support your research needs. Our experienced team of scientists and state-of-the-art facilities ensure accurate and reliable results. Whether you require cell viability assays, mechanistic investigations, or assistance with regulatory compliance, we are here to help you advance your scientific endeavors.

OUR EXPERTISE

KEY CONCEPTS IN CYTOTOXICITY STUDIES

ASSAY TECHNIQUE

A variety of assay techniques are used in cytotoxicity studies to measure cell viability. These techniques include the MTT assay, lactate dehydrogenase (LDH) release assay, ATP-based assays, and flow cytometry. Each assay has its strengths and limitations, and researchers choose the most appropriate technique based on their experimental requirements.

DOSE-RESPONSE RELATIONSHIP

Understanding the dose-response relationship is crucial in cytotoxicity studies. It involves determining the concentration or dose of a substance at which it starts exerting toxic effects on cells. By analyzing the dose-response relationship, researchers can establish the threshold at which a substance becomes harmful and determine its potency.

MECHANISM OF CELL DEATH

Cytotoxicity studies aim to uncover the mechanisms by which substances induce cell death. These mechanisms may include apoptosis (programmed cell death), necrosis (cell death due to injury or external factors), autophagy (self-degradation of cells), or other specific pathways. By elucidating the underlying mechanisms, researchers gain insights into the potential toxicological mechanisms of substances.

APPLICATION IN DRUG DEVELOPMENT

Cytotoxicity studies are an integral part of the drug development process. Before new drugs can be tested on humans, they undergo extensive cytotoxicity testing to evaluate their safety. These studies help identify potential adverse effects, determine safe dosage ranges, and guide further research and development.

WHY CHOOSE IBT?

EXPERTISE

Our team of scientists and technicians are highly skilled and experienced in conducting HAI assays, ensuring accurate and reliable results.

CUSTOMIZED SOLUTIONS

We understand the unique needs of each research project and provide customized assay designs to meet your specific requirements.

TIMELY RESULTS

We prioritize efficiency without compromising on quality. Our streamlined processes and advanced equipment allow for quick turnaround times, ensuring you receive results promptly.

QUALITY ASSURANCE

We maintain rigorous quality control measures throughout our operations, ensuring the accuracy and reproducibility of our assay results.

EXCEPTIONAL SUPPORT

Our dedicated customer support team is always available to address your queries and provide assistance at every step of the process.