Vaccine Immunogenicity and Efficacy Testing
The scientists at IBT Bioservices combined have over 50 years of experience in vaccine immunogenicity and efficacy studies in rodent models of infection. We have formed strong relationships with government agencies and industry partners validating our expertise in the vaccine development community. Our clients benefit from comprehensive sample collection capabilities including blood, tissue, and mucosal samples as needed. Samples can either be sent to your laboratory for further analysis or analyzed in our laboratories for pathogen-specific cellular and humoral immune responses or induction of cytokines or other biomarkers.
Assays Performed in vivo
Dosing
- Intranasal
- Intragastric
- Subcutaneous
- Intramuscular
- Intraperitoneal
- Hydrodynamic Shearing
- Intravenous
Immunogenicity
Antibody responses in:
|
Cellular responses in:
|
Tissue collection
- Spleen
- Lymph Nodes
- Bone Marrow
- Lung
- Liver
- Kidney
- GI Tract
- GU Tract
in vitro Serological Assay
The hemagglutination-inhibition test is a common test for the serological diagnosis of virus infections. Viruses have surface proteins that attach to red blood cells and cause them to agglutinate (hemagglutination). The basis for the hemagglutination-inhibition test (HAI) is antibodies against the viral protein will prevent the virus induced hemagglutination. Serum from the animal is tested to determine the minimum dilution that inhibits the hemagglutination. This is reported as the HAI titer of the serum.
Cytokine Analysis and Vaccine Efficacy
*See our biomarker services page for list of cytokines available for testing.
**Visit the Animal Model Testing page to view models currently available and in development.
Contact us today:
Email: services@ibtbioservices.com
Toll Free Phone: (877) 411-2041
Fax: (240) 778-6805